Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL
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چکیده
Murray W. Huff, Dawn E. Telford, Jane Y. Edwards, John R. Burnett, P. Hugh R. Barrett, Cholesterol and ApoB by Enhanced Plasma Clearance of LDL ApoB Inhibition of the Apical Sodium-Dependent Bile Acid Transporter Reduces LDL Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2002 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclerosis, Thrombosis, and Vascular Biology doi: 10.1161/01.ATV.0000035390.87288.26 2002; 2002;22:1884-1891; originally published online August 29, Arterioscler Thromb Vasc Biol. http://atvb.ahajournals.org/content/22/11/1884 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://atvb.ahajournals.org/content/suppl/2002/11/06/22.11.1884.DC1.html Data Supplement (unedited) at:
منابع مشابه
Inhibition of the apical sodium-dependent bile acid transporter reduces LDL cholesterol and apoB by enhanced plasma clearance of LDL apoB.
OBJECTIVE Cloning of the ileal apical sodium-dependent bile acid transporter (ASBT) has identified a new pharmacological target for the modulation of plasma lipoproteins. The objective of this study was to determine whether a novel, specific, minimally absorbed ASBT inhibitor (SC-435) decreases LDL cholesterol through the alteration of plasma apoB kinetics. METHODS AND RESULTS Miniature pigs ...
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